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Arylalkanolamine

From Wikipedia, the free encyclopedia

Arylalkanolamines (ArROHNR2) are a class of medicinal molecules that are structurally related to one another in certain respects.

Detailed understanding of their structure-activity relationship is expected to aid in drug discovery. [citation needed]

Phen(Aryl)alkanolamine. All molecules are α-aromatic-alcohols unless stated otherwise.
Compound Group 1/2/3° OH Α/Β/Γ/Δ Α/Β/Γ/Δ N Type of Pharmacology
PRC025 3-OH-2-BN-A γ-aminoalcohol β NHMe2 SN(D)RI
PRC200-SS PP-3-A " α,β NHMe NS(D)RI
Pridinol " " NC5H10 Anticholinergic (NMDA?)
Trihexyphenidyl (aka Benzhexol) " " " " "
Biperiden " " " " "
BDPC cyclohexanol δ-aminoalcohol γ,δ NMe2 μ/delta-opioid agonist
Tramadol " " 3 α-arylalcohol " μ-opioid agonist(prodrug, M1SNRI
Venlafaxine " " 2 β-arylalcohol " SNRI
Ciramadol " 3 γ-arylalcohol " μ-opioid mixed ant/agonist
Phenylpropanolamine PP-2-A 2 NH2 nor/adrenergic releaser
Cathine " " " " nor/adrenergic releaser
Ephedrine " " β-aminoalcohol NHMe nor/adrenergic releaser
Pseudoephedrine " " " " nor/adrenergic releaser
Dopamine " " " " endogenous neurotransmitter
Epinephrine ArE-2-A " " " neurotransmitter, also a hormone
Norepinephrine " " " NH2 neurotransmitter
Synephrine " " " " α1 agonist
Phenylephrine " " " " α1 agonist
Levalbuterol " " " NH(t-Bu) β-agonist
Clenbuterol " " " " "
Haloperidol Piperidinol δ 4,4 piper DA antagonist
Loperamide(Imodium AD) " " " " " μ-opioid agonist.